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Using phosphatase inhibitor beads coupled with mass spectrometry (PIB-MS) to parse phosphoprotein phosphatase signaling.
In our Nature Protocol, we present step by step instructions on how to make phosphatase inhibitor beads, enrich lysates for phosphoprotein phosphatases, multiplex, phosphopeptide enrich, and analyze samples by mass spectrometry to systematically study the major drivers of protein dephosphorylation.
Single cell Hi-C (scHi-C) maps chromatin spatial organization at single cell resolution, but the sparsity of the resulting data presents significant challenges in data analysis. We report a novel method, SnapHiC, which detects chromatin loops from scHi-C data at high sensitivity and specificity.