We present Spatial PAttern Recognition via Kernels (SPARK) as an effective statistical tool to identify genes with spatial expression patterns in spatially resolved transcriptomic studies. A particular feature of SPARK is its ability to produce calibrated p-values for spatial analysis.

An adaptive excitation source enables two- and three-photon imaging of the awake mouse brain with high spatial and temporal resolution at 30-fold-reduced laser power relative to conventional approaches.

Measuring ATG16L1 phosphorylation as an alternative method to monitor autophagy induction

The European XFEL (EuXFEL) is an X-ray source that produces femtosecond X-ray pulses at megahertz repetition rates. Time-resolved crystallographic investigations on biological reactions constitute an important class of experiments. We demonstrate how such a reaction is followed at the EuXFEL.

Self-coalescence occurs when a liquid is stretched and made to fold onto itself. Using microfluidics, their unique properties can be used to engineer and deliver precise sequences of reagents to realize complex portable bioassays.

Dynamic response of eukaryotes provide us with a signature of their response to stress, perturbations, sustained, cyclic, or periodic variations and fluctuations, and therefore the analysis of dynamic eukaryotic networks is elemental in achieving a mechanistic understanding of cellular behavior.

“Self-coalescence” of a liquid in a microstructure containing reagents can be programmed to master the dissolution profiles of picogram quantities of reagents in nanoliter volumes of solutions. This brings new options for chemistry and biosensing at the microscale.