Behind the Paper
Share the real story behind your paper, from conception to publication, the highs and the lows
Reduction of the illumination power for high-speed multiphoton microscopy
An adaptive excitation source enables two- and three-photon imaging of the awake mouse brain with high spatial and temporal resolution at 30-fold-reduced laser power relative to conventional approaches.
The search for a better protein marker of autophagy
Measuring ATG16L1 phosphorylation as an alternative method to monitor autophagy induction
Time-Resolved Serial Femtosecond Crystallography at the European XFEL
The European XFEL (EuXFEL) is an X-ray source that produces femtosecond X-ray pulses at megahertz repetition rates. Time-resolved crystallographic investigations on biological reactions constitute an important class of experiments. We demonstrate how such a reaction is followed at the EuXFEL.
Self-Coalescence physics: Understanding and using the fluid version of a zipper fastener
Self-coalescence occurs when a liquid is stretched and made to fold onto itself. Using microfluidics, their unique properties can be used to engineer and deliver precise sequences of reagents to realize complex portable bioassays.
Rational design and methods of analysis for the study of short- and long-term dynamic responses of eukaryotic networks
Dynamic response of eukaryotes provide us with a signature of their response to stress, perturbations, sustained, cyclic, or periodic variations and fluctuations, and therefore the analysis of dynamic eukaryotic networks is elemental in achieving a mechanistic understanding of cellular behavior.
The challenge of integrating and releasing reagents in microfluidics for biosensing
“Self-coalescence” of a liquid in a microstructure containing reagents can be programmed to master the dissolution profiles of picogram quantities of reagents in nanoliter volumes of solutions. This brings new options for chemistry and biosensing at the microscale.
Vascularized Brain Organoids
Genetic engineering to form vascular-like structures within cortical organoids (vhCOs).