Nature Methods
This journal is a forum for the publication of novel methods and significant improvements to tried-and-tested basic research techniques in the life sciences.
Identifying chromatin loops from single cells
Single cell Hi-C (scHi-C) maps chromatin spatial organization at single cell resolution, but the sparsity of the resulting data presents significant challenges in data analysis. We report a novel method, SnapHiC, which detects chromatin loops from scHi-C data at high sensitivity and specificity.
