Nature Methods
This journal is a forum for the publication of novel methods and significant improvements to tried-and-tested basic research techniques in the life sciences.
Designing next-generation norepinephrine indicators for in vivo imaging
We engineered a novel family of genetically-encoded fluorescent norepinephrine indicators in green and red. These indicators exhibit exceptional sensitivity, ligand-specificity, and temporal resolution, surpassing prior indicators and enabling the detection of norepinephrine in living animals.
Increasing single-cell data completeness and depth of coverage with prioritized proteomics
Prioritized analysis enables proteins of interest to be consistently quantified across single-cell samples at no cost to depth of coverage. Applied to primary macrophages, prioritization facilitated the quantification of proteolytically regulated proteoforms and the study of endocytic competency.
